Endocrine Abstracts

The role of hormones and reproductive factors in thyroid carcinoma is suggested by its higher incidence in women. The association with estrogens or other specific hormonal factors remains unclear. We assessed the estrogen receptor alpha (ESRa), estrogen receptor beta (ESRb) and progesterone receptor (PRR) expression in follicular cell-derived tumours (FDT).Cross-sectional study of 50 (25%) males, median age 50.5 (interquartile range, IR, 34), and 149 (75...

Background: Hyperandrogenism and disrupted folliculogenesis are prominent features of polycystic ovary syndrome (PCOS) and are causatively linked to ovarian dysfunction. In PCOS, increased anti-Müllerian hormone (AMH) serum levels have been observed and related to the severity of the phenotype. However, the regulation of AMH in PCOS remains poorly understood. Therefore, we compared AMH secretory pattern after acute exposure to a GnRH-analogue in women affected by PCOS or ...

Dopamine receptors (DR) are expressed in the majority of corticotroph pituitary tumors and the dopamine agonist cabergoline is effective in controlling cortisol hypersecretion in around 50% of patients with Cushing’s disease (CD). In order to characterize the tumors expressing D2 receptors and the profile of patients which might respond to the treatment with D2 agonists, the current study has the aim to correlate D2 receptor expression and...

Dopamine receptors was suggested to be expressed in medullary thyroid cancer (MTC). The aim of the current study was to evaluate the expression of D2 dopamine receptor in MTC and the effectiveness of the dopamine agonist cabergoline in patients with MTC. Five paraffin-embedded cases of MTC obtained after thyroidectomy were used to evaluate D2 receptor expression by immunohistochemistry. Fifteen patients (7 males, 8 females, 36–78 years) with post-sur...

Introduction: The demand of health care for people with gender incongruence (IG) has grown exponentially especially in young population. Due to this, there is a growing number of studies that show psychological conflicts and social functioning in those individuals who have not received gender-affirming treatment with medical intervention (pubertal block, hormone or surgical treatment) and social intervention. However, the data published so far do not represent the European cou...

Introduction: The 25hydroxyvitamin(OH)D deficiency has been linked to the risk of postmenopausal fractures and osteoporosis. In Colombia,the prevalence of 25(OH)vitaminD deficiency is high, reaching more than 53% of the total population. It can be stated that hip fracture is one of its most feared complications, with a high risk of mortality and morbidity,which can affect even osteopenic patients. The objective of this study is to assess modifications in hip T-score (using dua...

Radioiodide 131I (RAI) is the therapy of choice for radioiodine-avid differentiated thyroid cancer (DTC). However, 5–15% of DTC patients become RAI refractory (RAIR), and the 10-year survival rate for metastatic disease decreases to 10%. The failure of RAI response is mainly due to the loss of thyroid differentiation, that leads to the loss of expression/function of components of iodide metabolism, first of all the Na/I symporter (NIS). The finding that the MAPK pathway i...

Introduction: Immunohistochemistry (IHC) of somatostatin receptor subtype 2 (SST2) is a predictive factor for first-generation somatostatin receptor ligand (fg-SRL) response in acromegaly patients. A semi-quantitative immunoreactivity score, IRS, has been proposed as the gold-standard to evaluate SST2 IHC expression. Recently, our group developed a quantitative method to determine SST2 expression using an open-source digital image analysis (DIA...

A 52-year-old male patient with no past medical history of interest was admitted to our Endocrinology Unit with a clinical course developed in the last month of sudden polyuria, nocturia and polydipsia (8 liters/day) associated with bilateral low back and leg pain, a right-side nasal congestion with eye swelling and paresthesia. Physical examination revealed a doubtful thickening of the nasal mucosa and several two-cm- scattered erythematous disseminated skin lesions. Blood sa...

Introduction: Insulinoma, despite its low incidence of 0.4%, it is the most common functioning pancreatic neuroendocrine tumor. Most are benign, solitary and sporadic. Around 10% can be malignant and 5-10% are part of MEN-1. On certain occasions, the differential diagnosis is difficult when there is a history of Diabetes Mellitus (DM). Our objective was to describe clinical-epidemiological data and its diagnostic-therapeutic management.Materials and Meth...